PittsburghV1, Main, Exploration, bibRecord, 000873

Vesicle capture, not delivery, scales up neuropeptide storage in neuroendocrine terminals

Identifieur interne : 000873 ( Main/Exploration ); précédent : 000872; suivant : 000874

Vesicle capture, not delivery, scales up neuropeptide storage in neuroendocrine terminals

Auteurs : Dinara Bulgari ; Chaoming Zhou ; Randall S. Hewes ; David L. Deitcher ; Edwin S. Levitan

Source :

Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2014.

RBID : PMC:3948302

Descripteurs français

KwdFr :
- Animaux, Drosophila (physiologie), Microscopie confocale, Neuropeptides (métabolisme), Système neuroendocrinien (métabolisme), Système neuroendocrinien (physiologie), Terminaisons présynaptiques (métabolisme), Transmission synaptique (physiologie), Vésicules de transport (métabolisme), Vésicules de transport (physiologie).
MESH :
- métabolisme : Neuropeptides, Système neuroendocrinien, Terminaisons présynaptiques, Vésicules de transport.
- physiologie : Drosophila, Système neuroendocrinien, Transmission synaptique, Vésicules de transport.
- Animaux, Microscopie confocale.

English descriptors

KwdEn :
- Animals, Drosophila (physiology), Microscopy, Confocal, Neuropeptides (metabolism), Neurosecretory Systems (metabolism), Neurosecretory Systems (physiology), Presynaptic Terminals (metabolism), Synaptic Transmission (physiology), Transport Vesicles (metabolism), Transport Vesicles (physiology).
MESH :
- chemical , metabolism : Neuropeptides.
- metabolism : Neurosecretory Systems, Presynaptic Terminals, Transport Vesicles.
- physiology : Drosophila, Neurosecretory Systems, Synaptic Transmission, Transport Vesicles.
- Animals, Microscopy, Confocal.

Abstract

Significance

Neuropeptides, which affect mood and behavior, are synthesized in the soma and delivered to nerve terminals for storage and release. Yet, among identified neurons, there is great variation in the abundance of neuropeptides in terminals. Demonstrated transcriptional regulation of neuropeptide synthesis supports the view that presynaptic neuropeptide stores are proportional to synthesis-driven delivery of neuropeptide-containing vesicles to terminals. However, we show that nerve terminals with dramatically different neuropeptide stores are supported by identical vesicle delivery and differ instead in efficiency of vesicle capture. Vesicle capture in the terminal is under transcriptional control and influences vesicle distribution and replacement as well as neuropeptide accumulation for release. Thus, vesicle capture is a major determinant of nerve terminal function.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948302

DOI: 10.1073/pnas.1322170111
PubMed: 24550480
PubMed Central: 3948302

Affiliations:

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Vesicle capture, not delivery, scales up neuropeptide storage in neuroendocrine terminals

Vesicle capture, not delivery, scales up neuropeptide storage in neuroendocrine terminals

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

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